RV464

 

This study is intended to help understand the natural course of infection with human immunodeficiency virus (HIV) during the first few months. For this, the immune system of the participants and the virus will be monitored, more precisely the HIV symptoms, the CD4 + cell count and the HI virus load. The focus is on the changes that occur during the first weeks of HIV infection and the effects of HIV therapy on said changes. We also want to better understand the influence of individual physical characteristics of a person on the course of HIV infection. Therefore, the participants are requested to submit blood and urine samples at the study visits. Participants will also be asked to complete questionnaires on sexual behavior, as we want to better understand how HIV infections occur. This is important in order to be able to develop new, tailor-made HIV prevention methods in the future. For this study, we will recruit HIV-negative individuals, who have an increased HIV infection risk due to their sexual behavior. Within the framework of this study, we will discuss the various methods for HIV prevention and test them free of charge every three months for HIV and other sexually transmitted diseases, for example, syphilis or gonorrhea. However, participating in this study will not protect you from HIV infection!

The participants are examined and observed at the HPSTD clinic in Essen or at the practice Jenssen² + Colleagues in Berlin. For some of the participants, participation in other studies may also be appropriate, in which new ways of treating HIV infection are to be investigated, with which the virus in the body can be contained without the patient having to use drugs all his life.

Participation Requirements

Inclusion Criteria:

–   You must be at least 18 years of age

–   You:

  • have an acute HIV-infection

         or

  • have a chronic HIV-infection and either:
    • have not taken antiretroviral (ART) medication for at least 6 months or
    • have never taken antiretroviral medication

         or

  • are not infected with HIV, were born a male, and have in the last 24 months either:
    • had unprotected anal intercourse with at least two different male partners (the partners were infected with HIV or their status was unknown) or
    • a documented syphilis infection or
    • a documented rectal gonorrhea or chlamydia infection

 

Exclusion Criteria:

  • You suffer from a major (medical, psychological/psychiatric or social) disorder or disorder that could affect the performance of the study
  • You currently have an alcohol or substance dependency, which could impair compliance with the study regulations
  • You are currently participating in a study on preventive or therapeutic HIV vaccines or have participated in such a study in the past
  • You have taken a drug for a trial phase within 28 days before the start of the study
  • You must take medication for another condition that may affect your immune system (e.g. steroids or chemotherapeutic agents)
  • You are/will be pregnant at the start of the study