Dr. Jeffrey Teigler is a postdoctoral fellow in the laboratory of Hendrik Streeck at the U.S Military HIV Research Program. He is keenly interested in the interfaces between scientific fields. This interest led him to obtain undergraduate degrees in Biochemistry & Molecular Biology as well as German language from Ursinus College. Following his undergraduate studies, he was awarded a J. William Fulbright Fellowship to study public health interventions as well as familial genetics at Eberhard Karls Universität in Tübingen, Germany. He then decided to pursue graduate studies at the Program in Virology at the Division of Medical Sciences at Harvard University. There, he performed his graduate thesis work in the laboratory of Dr. Dan H. Barouch and wrote his dissertation on the differential innate immune stimulatory properties and mechanisms of adenovirus and poxvirus vaccine vectors. The originality and importance of his graduate work was recognized through his being named one of the eight inaugural Harvard Horizons scholars, chosen across all programs in the Graduate School for Arts and Sciences at Harvard University.
Dr. Teigler is deeply interested in the means by which immune responses are programmed by different stimuli, and how these processes can be harnessed to generate novel and powerful immunotherapeutics against important infections and cancers. Currently, he is developing innovative methods of testing vaccines and therapies in a rapid and patient-specific manner to more efficiently generate vaccines. He is furthermore exploring novel ways in which the human immune system targets and interacts with infections.
Awards and Honors:
Harvard Horizons Scholar – 2013
National Defense Science and Engineering Graduate Fellowship – 2009-2012
Herchel Smith Graduate Fellowship (Harvard University) – 2008-2009
National Science Foundation East Asia and Pacific Summer Institutes – 2009
J. William Fulbright Fellowship – 2007-2008
Barry M. Goldwater Scholarship – 2006
Abbink, P., Maxfield, L.F., Ng’ang’a, D., Borduchi, E., Bricault, C., Iampietro, M.J., Teigler, J.E., Blackmore, S., Parentheau, L., Korber, B., Virgin, S., Barouch, D.H. Isolation and Construction of Novel Rhesus Monkey Adenovirus Vaccine Vectors. In Press.
Teigler, J.E., Kagan, J.C., and Barouch, D.H. Differential Late Endosomal Trafficking by Adenovirus Vector Serotypes Confers Increased Stimulation of Innate Sensing Pathways. J.Virol. 88(18):10354-10363.
Teigler, J.E., Penaloza-MacMaster, P., Obeng, R., Provine, N.M., Larocca, R.A., Borducchi, E.N., Baker, A., and Barouch, D.H. Hexon Hypervariable Region-Modified Adenovirus 5 Vectors Display Reduced Hepatotoxicity but Induce T Lymphocyte Phenotypes Similar to Ad5 Vectors. Clin.Vaccine Immunol. 21(8):1137-1144.
Penaloza-Macmaster P, Teigler JE, Obeng RC, Kang ZH, Provine NM, Parenteau L, Blackmore S, Ra J, Borducchi EN, Barouch DH. (2014). Augmented replicative capacity of the boosting antigen improves the protective efficacy of heterologous prime-boost vaccine regimens. J Virol. 88 (11):6243-54.
Teigler, J.E., Phogat, S., Franchini, G., Hirsch, V.M., Michael, N.L., and Barouch, D.H. The Canarypox Vector ALVAC Induces Higher Cytokine Responses Compared to the Vaccinia-Based Vectors MVA and NYVAC in Rhesus Monkeys. J Virol. 88 (3):1809-14.
Teigler, J.E., Iampietro, M.J., and Barouch, D.H. 2012. Vaccination with Adenovirus Serotypes 35, 26, and 48 Elicits Greater Innate Cytokine Responses Than Adenovirus Serotype 5 in Rhesus Monkeys. 2012. Journal of Virology. 86 (18): 9590-8.
Li, H., Rhee, E.G., Masek-Mammerman, K., Teigler, J.E., Abbink, P., and Barouch, D.H. Adenovirus Serotype 26 Utilizes CD46 as a Primary Cellular Receptor and Only Transiently Activates T Lymphocytes Following Vaccination of Rhesus Monkeys. 2012. Journal of Virology. 86 (19):10862-5.
Altamura, L.A., Bertolotti-Ciarlet, A., Teigler, J., Paragas, J., Schmaljohn, C.S. and Doms, R.W. 2007. Identification of a novel C-terminal cleavage of Crimean-Congo hemorrhagic fever virus PreGN that leads to generation of an NSM protein. Journal of Virology 81 (12):6632-6642