Dr. Michael Storcksdieck genannt Bonsmann is a postdoctoral research fellow at the Institute of HIV Research. He received his Master’s Degree in Biochemistry with a major in Molecular Medicine from the Ruhr-University Bochum. During his Master’s studies at Prof. A. Bufe’s Department for Experimental Pneumology, he investigated an antiviral activity against the Respiratory Syncytial Virus (RSV) in barn dust extracts as a possible explanation for the reduced risk for asthma in children from rural areas. For his doctorate, he joined Prof. K. Überla’s Department of Molecular and Medical Virology. Here, he studied the potential of HIV-1 GagPol-specific CD4+ T cells to enhance the quality of Env-specific antibodies in a preclinical small animal model. After a short post doctorate focused on vaccine-induced HBV-specific T helper cells, he joined the Streeck Lab at the University Hospital Essen to expand his knowledge on HIV-specific CD4+ T cells and their role in vaccine development.
Awards and Honors:
| Speaker Bill & Melinda Gates Foundation USA |
Norman L. Letvin Early Career Investigator Session, 9th Annual Meeting of the Collaboration for AIDS Vaccine Discovery (CAVD), Seattle, 2014 |
| Travel Grant Bill & Melinda Gates Foundation USA |
Science Exchange Program; month-long visit of the Ackerman Lab, Thayer School of Engineering, Dartmouth College, Hanover, NH, USA, in October 2014 to analyze the glycosylation of HIV-1 Env-specific antibodies |
| Doctoral Scholarship Ruhr-University Bochum, Germany |
Scholarship of the Research School, the graduate school of the Ruhr-University funded by the Excellence Initiative of the Deutsche Forschungsgemeinschaft |
Scientific Publications:
Storcksdieck genannt Bonsmann, M, Niezold, T, Hannaman, D, Überla, K, Tenbusch, M. 2015. The improved antibody response against HIV-1 after a vaccination based on intrastructural help is complemented by functional CTL responses. In revision at Vaccine.
Storcksdieck genannt Bonsmann, M, Niezold, T, Temchura, V, Pissani, F, Ehrhardt, K, Brown, EP, Osei-Owusu, NY, Hannaman, D, Hengel, H, Ackerman, ME, Streeck, H, Nabi, G, Tenbusch, M, Überla, K. 2015. Enhancing the Quality of Antibodies to HIV-1 Envelope by GagPol-Specific Th Cells. The Journal of Immunology, 195(10), 4861–4872.
Niezold, T, Storcksdieck genannt Bonsmann, M, Maaske, A, Temchura, V, Heinecke, V, Hannaman, D, Buer, J, Ehrhardt, C, Hansen, W, Überla, K, Tenbusch, M. 2015, DNA vaccines encoding DEC205-targeted antigens: Immunity or Tolerance? Immunology.
Nabi, G, Genannt Bonsmann, MS, Tenbusch, M, Gardt, O, Barouch, DH, Temchura, V, Überla, K. 2013. GagPol-specific CD4+ T cells increase the antibody response to Env by intrastructural help. Retrovirology 10: 117.
Johrden, L, Tenbusch, M, Lietz, R, Bonsmann, MSG, Niezold, T, Wildner, O, Bayer, W. 2013. Comparison of polystyrene nanoparticles and UV-inactivated antigen-displaying adenovirus for vaccine delivery in mice. Virology Journal 10: 108.
Stab, V, Nitsche, S, Niezold, T, Storcksdieck genannt Bonsmann, M, Wiechers, A, Tippler, B, Hannaman, D, Ehrhardt, C, Überla, K, Grunwald, T, Tenbusch, M. 2013. Protective Efficacy and Immunogenicity of a Combinatory DNA Vaccine against Influenza A Virus and the Respiratory Syncytial Virus. PLoS ONE 8: e72217.
Tenbusch, M, Nchinda, G, Storcksdieck genannt Bonsmann, M, Temchura, V, Überla, K. 2013. Targeting the antigen encoded by adenoviral vectors to the DEC205 receptor modulates the cellular and humoral immune response. Int. Immunol. 25: 247–258.
Lietz, R, Bayer, W, Ontikatze, T, Johrden, L, Tenbusch, M, Bonsmann, MSG, Überla, K, Dittmer, U, Wildner, O. 2012. Codelivery of the chemokine CCL3 by an adenovirus-based vaccine improves protection from retrovirus infection. J Virol 86: 1706–1716.
Kamdem Toukam, D, Tenbusch, M, Stang, A, Temchura, V, Storcksdieck genannt Bonsmann, M, Grewe, B, Koch, S, Meyerhans, A, Nchinda, G, Kaptue, L, Überla, K. 2012. Targeting antibody responses to the membrane proximal external region of the envelope glycoprotein of human immunodeficiency virus. PLoS ONE 7: e38068.
Tenbusch, M, Grunwald, T, Niezold, T, Storcksdieck Genannt Bonsmann, M, Hannaman, D, Norley, S, Überla, K. 2010. Codon-optimization of the hemagglutinin gene from the novel swine origin H1N1 influenza virus has differential effects on CD4(+) T cell responses and immune effector mechanisms following DNA electroporation in mice. Vaccine 28: 3273–3277.
Scientific Talks:
Storcksdieck genannt Bonsmann, M, Niezold, T, Temchura, V, Pissani, F, Ehrhardt, K, Brown, EP, Osei-Owusu, NY, Hannaman, D, Hengel, H, Ackerman, ME, Streeck, H, Nabi, G, Tenbusch, M, Überla, K. 2015. Overcoming a bias in the quality of the HIV-1 Env-specific antibody response by intrastructural help. Virologisches Seminar, Erlangen, Germany
Storcksdieck genannt Bonsmann, M, Niezold, T, Temchura, V, Pissani, F, Ehrhardt, K, Brown, EP, Osei-Owusu, NY, Hannaman, D, Hengel, H, Ackerman, ME, Streeck, H, Nabi, G, Tenbusch, M, Überla, K. 2015. Overcoming a bias in the quality of the HIV-1 Env-specific antibody response by intrastructural help. 25th Annual Meeting of the Society for Virology, Bochum, Germany
Storcksdieck genannt Bonsmann, M, Niezold, T, Temchura, V, Pissani, F, Ehrhardt, K, Brown, EP, Osei-Owusu, NY, Hannaman, D, Hengel, H, Ackerman, ME, Streeck, H, Nabi, G, Tenbusch, M, Überla, K. 2014. Overcoming a bias in the quality of the HIV-1 Env-specific antibody response by intrastructural help. Norman L. Letvin Early Career Investigator Session, 9th Annual Meeting of the Collaboration for AIDS Vaccine Discovery, Bill & Melinda Gates Foundation, Seattle
Storcksdieck genannt Bonsmann, M, Niezold, T, Temchura, V, Pissani, F, Ehrhardt, K, Hannaman, D, Hengel, H, Streeck, H, Nabi, G, Tenbusch, M, Überla, K. 2014. Overcoming a bias in the quality of the HIV-1 Env-specific antibody response by intrastructural help. 44th Annual Meeting of the German Society for Immunology, Bonn, Germany
Storcksdieck genannt Bonsmann, M, Niezold, T, Temchura, V, Ehrhardt, K, Hannaman, D, Hengel, H, Nabi, G, Tenbusch, M, Überla, K. 2014. Heterologous T-cell help to enhance FcγR-mediated effector functions of HIV-1 vaccine elicited antibodies. 24th Annual Meeting of the Society for Virology, Alpbach, Austria
Storcksdieck genannt Bonsmann, M. 2011. The role of functional antibodies in vivo. Europrise PhD course: Frontiers in HIV Vaccines and Microbicides, Stockholm, Sweden